Biopolymers and cell. 1988. Volume 4. № 5. 245 - 250

A. G. Sergeev, A. R. Pavlov, E. O. Zhazhina, V. V. Basevich, A. I. Yaropolov

THE INFLUENCE OF CERULOPLASMIN, LACCASE AND SUPEROXIDE DISMUTASE ON THE LEVEL OF SUPEROXIDE RADICALS

Summary

    Ceruloplasmin (CP) and laccase were studied for their effect on the xanthine/xanthine oxidase (Xan/XOD) and NADH/phenasine methasulphate (PMS) O2^-generating systems. It was shown that the kinetic action of these enzymes differs from that of superoxide dismulase (SOD). While SOD scavenges immediately O2~, then CP and laccase react with a predecessor of O2~ demonstrating clearly their role as electron acceptors. The results indicate that the CP acts as possible universal oxidase of mammalian and human serum.