Biopolymers and cell. 1988. Volume 4. № 2. 105 - 107

E. A. Erenpreisa, T. G. Sjakste

STIMULATION OF RNA SYNTHESIS BY DIMETHYL SULPHOXIDE DEPENDS ON THE DEVELOPMENTAL STAGE OF THE TRANSFORMED CELLS CULTURE

Summary

    The work has been carried out by the method of quantitative pulse 3H-uridine autoradio-graphy on the line 4/21 of transformed hamster fibroblasts. As previously stated on Zaj-dela ascite hepatoma 2 h treatment with 1 % DMSO causes 2-3-fold enhancing of RNA synthesis. However, it manifests only on 24 h culture with the low ground level of RNA synthesis. The later cultures with the high RNA-synthetic activity do not respond. The trigger-like mechanism of DMSO action is discussed.