Biopolymers and cell. 1987. Volume 3. № 4. 171 - 178

V. D. Fedotov, L. S. Kivaeva

NEW MODIFICATION OF THE MODEL-FREE APPROACH TO ANALYSIS OF DATA ON NUCLEAR MAGNETIC RELAXATION IN PROTEINS

Summary

    A formal approach to the analysis of data on magnetic relaxation of 13C nuclei in proteins is developed. It is based on ideology which has been used by one of the authors to study internal motions in solid polymers. According to the approach the intramolecular motions in proteins are considered as anisotropic ones and are characterized by a spectrum of the correlation times. A set of the formal microdynamic parameters such as an aniso-tropy parameter (a measure of spatial motion restriction), the most probable correlation time, a parameter of the correlation time distribution width is introduced to describe these motions. The causes resulting in non-exponential correlation function of local motion are discussed as well as a relation between formal parameters and microdynamic characteristics for concrete models of the motion.