Biopolymers and cell. 1987. Volume 3. № 1. 22 - 26, 40

A. P. Potapov, B. N. Goldstein, S. R. Saifullin, A. V. Elskaya

ANALYSIS OF THE KINETIC SCHEME FOR THE PROTEIN SYNTHESIS ELONGATION STAGE WITHIN HYPOTHESIS ON THE STEREOSPECIFIC STABILIZATION OF THE CODON-ANTICODON COMPLEXES BY RIBOSOME. 1. THE RATE OF POLYPEPTIDE CHAIN ELONGATION

Summary

    A kinetic analysis of a steady-state polypeptide chain elongation is presented based on the hypothesis of stereospecific stabilization of the codon-anticodon complexes by ribosome during aa-tRNA selection and translocation stages. Equations have been obtained describing the dependence of the elongation rate on concentrations of aa-tRNA, aa-tRNA-£F-r«-GTP complex, EF-Tu-GTP and EF-G-GTP complexes.