Biopolymers and cell. 1985. Volume 1. № 6. 283 - 307

R. Sh. Baabealashvilli, Z. G. Chidgeavadze, A. A. Krayevsky, M. K. Kukhanova, A. M. Atrazhev, A. V. Azhaev, T. V. Kutateladze

NEW INHIBITORS OF DNA AND RNA BIOSYNTHESIS IN VITRO AND IN VIVO

Summary

    This review summarizes the authors' data on the pathways of the synthesis and properties of a great number of new inhibitors of DNA and RNA biosynthesis in vitro and in yivo. The molecular mechanism of the action of these inhibitors in the reactions of polymerization, pyrophosphorolysis and hydrolysis is determined using individual tem-platfts with involvement of purified DNA and RNA polymerases. Some of these inhibitors are shown to be applicable fo studying of replication in the culture of eukaryotic cells, in embryos and cell nuclei, as well as for repairing DNA in chromatin