Biopolymers and cell. 1985. Volume 1. № 4. 171 - 179

A. A. Akhrem, A. S. Fridman, D. Yu. Lando

THEORY OF HELIX-COIL TRANSITION OF THE HETEROGENEOUS DNA-HETEROQENEOUS LIGANDS COMPLEXES

Summary

    A theory is suggested for describing the helix-coil transition of heterogeneous DNA with a given primary structure in the presence of heterogeneous ligands which are characte¬rized by the contact interaction with each other under adsorption on DNA, by extension and selective binding with definite sequences of base pairs. The ligand heterogeneity and the influence of boundaries between coil and helix regions on the complex melting are taken into account in the theory. An algorithm is developed for calculating the melting curve, the melting and relative concentration of ligands bound to coil and helix DNA regions as well as for other characteristics of the DNA-ligand complex.