Biopolymers and cell. 1985. Volume 1. № 1. 21 - 25
Yu. N. Alexandrov, S. M. Gershenson
SELECTIVITY OF MUTAGENIC ACTION OF SYNTHETIC POLYNUCLEOTIDES
Summary
Solutions of high molecular weight synthetic polyriboadenylic, polyriboinosylic, polyribouridylic, polyriboadenylic-cytidylic, polydeoxyadenylic and -polydeoxythymidylic acids injected into Drosophila melanogaster males caused a 6-16 time increase of the overall frequency of recessive lethals in the 2nd chromosome. Complementation analysis of the induced lethals showed an extremely high locus-specificity for some of these mutagens. Distribution along the chromosome of induced lethals is different for different polynucleotides. Possible mechanisms of the mutagenic action of synthetic polynucleotides are discussed.