Biopolymers and cell. 1985. Volume 1. № 1. 5 - 13
V. I. Ivanov
B-A TRANSITION IN DNA AND TRANSCRIPTION
Summary
The paper deals with the current progress in elucidation of the significance of the A form of DNA in transcription and its regulation. The three aspects are considered: (1) the B-A transition during RNA polymerase operation, (2) the studies on the physics of the B-A transition with the aim to obtain thermodynamic parameters of this transformation and such properties as sequence effect which might be indicative of the possibility for an active role of the B-A transition in gene regulation, (3) a conformational hypothesis on the operation mechanism for the activator of bacterial operons, the CAP protein. 12